Progesterone Isoforms and Endometrial Cancer
نویسندگان
چکیده
منابع مشابه
Distribution of estrogen and progesterone receptors isoforms in endometrial cancer
BACKGROUND 70-80% of sporadic endometrial carcinomas are defined as endometrioid carcinoma (EC). Early-stage, well differentiated endometrial carcinomas usually retain expression of estrogen and progesterone receptors (ER and PR, respectively), as advanced stage, poorly differentiated tumors often lack one or both of these receptors. Well-described EC prognosis includes tumor characteristics, s...
متن کاملInverse Relationship between Progesterone Receptor and Myc in Endometrial Cancer
Endometrial cancer, the most common gynecologic malignancy, is a hormonally-regulated disease. Response to progestin therapy positively correlates with hormone receptor expression, in particular progesterone receptor (PR). However, many advanced tumors lose PR expression. We recently reported that the efficacy of progestin therapy can be significantly enhanced by combining progestin with epigen...
متن کاملProgesterone receptor isoforms A and B: new insights into the mechanism of progesterone resistance for the treatment of endometrial carcinoma
Progesterone therapy is an effective treatment for atypical endometrial hyperplasia and early endometrial carcinoma (EC). However, progesterone resistance is the main obstacle to the success of conservative treatment in women with type I EC and remains a major clinical challenge. Studies indicate that progesterone and progesterone receptors (PRs) play a significant role in both normal and neopl...
متن کاملProgesterone receptor isoform identification and subcellular localization in endometrial cancer.
OBJECTIVE These studies were undertaken to characterize the subcellular localization of the two major isoforms of progesterone receptors (PR), PRA and PRB, in endometrial cancer. METHODS Immunohistochemistry, immunoprecipitation, and confocal microscopy were performed using Hec50co and KLE endometrial cancer cell models expressing PRA or PRB as a consequence of transduction. The location of P...
متن کاملEndometrial cancer
کانسر آندومتر شایعترین بدخیمی دستگاه تناسلی زنان است، که تقریبا 7 درصد کانسرهای زنان را شامل می شود و چهارمین کانسر زنان بعد از کانسرهای (پستان، ریه و کلورکتال) در آمریکا است.
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ژورنال
عنوان ژورنال: Journal of the Society for Gynecologic Investigation
سال: 2005
ISSN: 1071-5576
DOI: 10.1016/j.jsgi.2005.02.013